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. 2022 Jan 5;12(1):210220. doi: 10.1098/rsob.210220

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Proposed model showing how dynamic signalling activity can feed into paused Pol II to encode distinct cell fates. In models where a progenitor is specified to either cell fate A or cell fate B by different levels and/or dynamics of signalling activity, pausing can ‘prime’ the cell fate A gene network. A short temporal pulse of signalling can thus lead to pause-release and activation of gene network A and cell fate A specification. Mutual inhibition of opposing cell fate gene networks allows gene network A to repress cell fate B. Sustained signalling activity is required for sufficient induction of gene network B and establishment of cell fate B.