Table 4.

Comparisons between post-COVID and de novo PD patients with hyposmia

Cluster extent	Cluster level	Cortical region	Peak level		Talairach coordinates		cortical region	BA
	Corrected p value		Maximum z-score
A Relative hypometabolism in post-COVID patients
781	0.012
		R-frontal	6.5	32	2	36	Middle frontal gyrus	6
		R-temporal	5.73	44	6	− 32	Medial temporal gyrus	21
		R-temporal	5.68	44	− 24	− 8	Superior temporal gyrus	22
		R-frontal	5.61	32	10	20	Insula	13
		L-temporal	5.26	− 36	− 4	− 32	Middle temporal gyrus	21
		L-temporal	5.22	− 34	4	− 20	Superior temporal gyrus	38
		L-frontal	5.11	− 10	26	− 8	Middle frontal gyrus	11
B Relative hypometabolism in de novo PD patients
1964	0.002
		R-occipital	8.4	38	− 92	− 2	Inferior occipital gyrus	18
		R-occipital	8.33	8	− 102	10	Cuneus	18
		L-occipital	8.25	− 10	− 90	36	Cuneus	19
		L-occipital	8.22	− 34	− 86	6	Middles occipital gyrus	19

p < 0.05

FWE-corrected both at peak and cluster level were accepted as statistically significant. In the “cluster level” section on the left, the corrected p value and the brain lobe with hypometabolism are reported. In the “peak level” section on the right, the z-score and peak coordinates, the corresponding cortical region, and Brodmann area (BA) are reported

L, left; R, right