Scheme 14.
Synthetic scheme for 3,5-disusbtituted 1,2,4-oxadiazoles (89) as anti-fungal agents. Conditions: (i) MeOH, reflux, 8 h; (ii) CuCN, L-proline, DMF, 11 h; (iii) EtOH, rt; (iv) PhMe; (v) NaOH, THF, 2 h; (vi) 0 °C, 8 h
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