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. 2022 Jan 5;26(5):2967–2980. doi: 10.1007/s11030-021-10375-4

Scheme 2.

Scheme 2

Synthetic strategy for 3-aryl-5-propyl-1,2,4,oxadiazoles (12) reported by Srivastava and co-workers. Conditions: (i) EtOH, H2O, rt, 5–8 days; (ii) MnO2, (3.8 equiv), DCM, rt, 2 h