Scheme 3.
Synthesis of 3-(4-susbstituted-aryl)-1,2,4-oxadiazolyl-N-acylhydrozone (18) acting against T. cruzi. Conditions: (i) THF, reflux, 4.5 h; (ii) EtOH, 0 °C, 60 min; (iii) H2SO4, EtOH, rt,10 min
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