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Synthetic strategy of 3,5-disubstituted oxadiazoles (16 and 22) as trypanosomicidal and anti-malarial agents. Conditions: (i) Na2CO3, H2O/MeOH, 4 h, reflux; (ii) dry THF, reflux, 4–4.5 h; (iii) EtOH, 0 °C, 2 h; (iv) H2SO4 or CeCl3.7H2O (10 mol%), EtOH, 40 °C,10–30 min
