Scheme 7.
Synthesis of nitrofuryl substituted 3-amino-1,2,4-oxadiazoles (39/40) and 5-amino-1,2,4-oxadiazoles (42/43) having potent anti-microbial activity. Conditions: (i) HNO3, Ac2O, 15 °C, 30 min; (ii) 10% HCl (ethanolic), 3 h
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