Scheme 9.
Structure activity relationship of 1,2,4-oxadiazole antibiotics 58. Conditions: (i) K2CO3, DMF, 60–100 °C or Cul, Cs2CO3, N,N-dimethylglycine.HCl 1,4-dioxane, 90 °C; (ii) NH2OH, EtOH and (iii) pyridine/toluene/1,4-dioxane
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