Table 2.
Response to medical treatment and outcome of 75 patients with autoimmune liver diseases
|
Variables
|
All patients, n = 75
|
AIH, n = 54
|
ASC, n = 21
|
P
value
|
| Treatment, n | ||||
| Prednisone alone | 26 (35%) | 19 (35%) | 7 (33%) | 1 |
| Prednisone + Azathioprine | 30 (40%) | 28 (52%) | 2 (10%) | < 0.001 |
| Prednisone + MMF | 5 (7%) | 3 (5%) | 2 (10%) | 0.615 |
| Prednisone + Vancomycin | 4 (5%) | 1 (2%) | 3 (14%) | 0.064 |
| Prednisone + Azathioprine + Vancomycin | 2 (3%) | 0 (0%) | 2 (10%) | 0.075 |
| Prednisone + MMF + Vancomycin | 6 (8%) | 1 (2%) | 5 (23%) | 0.005 |
| Prednisone + Tacrolimus | 1 (1%) | 1 (2%) | 0 | NA |
| Cyclosporine | 1 (1%) | 1 (2%) | 0 | NA |
| Response to treatment | ||||
| Normal AST (NV ≤ 45 U/L): n | 69 (92%) | 52 (96%) | 17 (81%) | 0.048 |
| Time to normalize AST (yr) | 0.1 (0.1-0.5) | 0.2 (0.1-0.6) | 0.1 (0.1-0.2) | 0.19 |
| GGT (< 50 UI/L), n | 68 (91%) | 51 (94%) | 17 (81%) | 0.811 |
| Time to normalize GGT (yr) | 0.3 (0.2-0.6) | 0.3 (0.2-0.5) | 0.3 (0.2-1.1) | 0.062 |
| Immunological remission1: n | 25 (33%) | 22 (40%) | 3 (14%) | 0.032 |
| Time to immunological remission | 3.1 (2.2-4.2) | 3.8 (2.9-4.3) | 3.4 (3.2-3.7) | 0.86 |
| Relapse of AILD during treatment, n | ||||
| At least one relapse | 36 (48%) | 22 (41%) | 14 (67%) | < 0.070 |
| 1 relapse alone | 26 (35%) | 17 (31%) | 9 (43%) | 0.421 |
| ≥ 2 relapses | 10 (13%) | 5 (9%) | 5 (24%) | 0.131 |
| Outcome at last follow up | ||||
| Median follow up, yr (range) | 4.4 (0.6-13.8) | 4.1 (1.2-11.7) | 4.5 (0.6-13.8) | 0.079 |
| Alive | 75 (100%) | 54 (100%) | 21 (100%) | NA |
| OFF-IS therapy | 6 (8%) | 5 (9%) | 1 (5%) | 0.666 |
| Medical treatment | 68 (91%) | 49 (91%) | 19 (90%) | 1 |
| Liver transplant | 1 (1%) | 0 (0%) | 1 (5%) | 0.28 |
1
Normal aspartate aminotransferase, normal IgG, and negative or low titer autoantibodies.
AIH: Autoimmune hepatitis; ASC: Autoimmune sclerosing cholangitis; AST: Aspartate aminotransferase; MMF: Mycophenolate mofetil; GGT: Gamma-glutamyl transferase; IS: Immunosuppressive; NA: Not applicable; ALID: Autoimmune liver disease; NV: Normal value.