. 2021 Dec 27;13(12):2052–2070. doi: 10.4254/wjh.v13.i12.2052

Table 2.

Correlation of steatohepatitis, cardiovascular risk, and microbiota composition

Variable¹		Severity and progression of liver injury				CVR factors and metabolism of lipids						Cardiomyocyte morphometry			Microbiota composition
Variable¹		Quantification of collagen (picrosirius)	TIMP-1	MCP-1	IL-1β	miR-33a	miR-126	PAI-1	CRI-I	CRI-II	AC	% Normal CAR	Average area of CAR	% Atrophic CAR
Severity and progression of liver injury	NAFLD score	0.879²	0.791²	0.673²	0.347	0.639²	-0.777²	0.444³	0.809²	0.820²	0.809²	-0.519³	-0.630²	0.721²	0.694²
	Quantification of collagen (picrosirius)		0.611²	0.456³	0.752²	0.571³	-0.683²	0.415	0.819²	0.821²	0.819²	-0.205	-0.312	0.238	0.378²
	TIMP-1			0.803²	0.726²	0.728²	-0.812²	0.535³	0.691²	0.747²	0.691²	-0.694²	-0.405	0.607²	0.539²
	MCP-1				0.567³	0.492³	-0.623²	0.336	0.549³	0.561³	0.549³	-0.490³	-0.390	0.498³	0.232³
	IL-1β					0.809²	-0.688³	0.544³	0.645³	0.688²	0.645³	-0.437³	-0.393	0.382	0.293³
CVR factors and metabolism of lipids	miR-33a						-0.655²	0.363	0.529³	0.603³	0.529³	-0.704²	0.038	0.232	0.160³
	miR-126							-0.634²	-0.712²	-0.730²	-0.712²	0.459³	0.320	-0.364	0.368²
	PAI-1								0.487³	0.671²	0.487³	-0.317	0.389	-0.289	0.103
	CRI-I									0.863²	1.000²	-0.234	-0.459³	0.386	0.469²
	CRI-II										0.863²	-0.399	-0.492³	0.551³	0.584²
	AC											-0.236	-0.457³	0.389	0.477²
Cardiomyocyte morphometry	% Normal cardiomyocytes												0.105	-0.058
	% Average area of cardiomyocytes													-0.818²
	% Atrophic cardiomyocytes

Variables were evaluated by Spearman's r correlation coefficient: moderate (0.3 < r < 0.6), strong (0.6 < r < 0.9) or very strong (0.9 < r < 1.0).

Correlation significant at the 0.01 level.

Correlation significant at the 0.05 level.

AC: Atherogenic coefficient; CAR: Cardiomyocytes; CRI: Castelli’s risk index; CVR: Cardiovascular risk; IL: Interleukin; MCP: Monocyte chemoattractant protein; NAFLD: Nonalcoholic fatty liver disease; PAI: Plasminogen activator inhibitor; TIMP: Tissue inhibitor of metalloproteinase.