Table 3.
Correlation of gut microbiota at family level, steatohepatitis, and cardiovascular risk factors
|
Variable1 (Family)
|
Severity and progression of liver injury
|
CVR factors and metabolism of lipids
|
||||||||
|
NAFLD score
|
Quantification of collagen (picrosirius)
|
TIMP-1
|
MCP-1
|
miR-33a
|
miR-126
|
PAI-1
|
CRI-I
|
CRI-II
|
AC
|
|
| Actinomycetaceae | 0.5842 | |||||||||
| Aerococcaceae | ||||||||||
| Anaeroplasmataceae | -0.5532 | -0.6142 | -0.6142 | |||||||
| Atopobiaceae | 0.6272 | 0.6102 | 0.5922 | 0.6632 | 0.5922 | |||||
| Bacillales_unclassified | 0.5492 | -0.5482 | -0.5332 | -0.5482 | ||||||
| Bacteroidaceae | 0.8362 | 0.7462 | 0.7842 | 0.6892 | -0.7542 | 0.6622 | 0.7322 | 0.6622 | ||
| Bacteroidales_unclassified | -0.5602 | -0.5892 | -0.4922 | |||||||
| Burkholderiaceae | 0.5642 | |||||||||
| Clostridiaceae | 0.8072 | 0.7232 | 0.6452 | 0.5932 | -0.6692 | 0.6762 | 0.6382 | 0.6762 | ||
| Clostridiales_unclassified | -0.6282 | -0.5292 | -0.5352 | -0.5762 | -0.5862 | -0.5252 | ||||
| Clostridiales_vadinBB60 | -0.6022 | -0.6712 | -0.5272 | -0.5582 | 0.5242 | -0.6262 | -0.5022 | -0.6262 | ||
| Corynebacteriaceae | -0.6692 | -0.5452 | -0.6802 | -0.7822 | 0.6112 | -0.5712 | -0.6222 | -0.5712 | ||
| Desulfovibrionaceae | -0.8062 | -0.6032 | -0.8722 | -0.7762 | -0.6312 | 0.7552 | -0.7292 | -0.7462 | -0.7292 | |
| Eggerthellaceae | 0.4902 | |||||||||
| Firmicutes_unclassified | -0.7972 | -0.6372 | -0.6872 | -0.6552 | 0.5942 | -0.6292 | -0.6992 | -0.6292 | ||
| Gastranaerophilales | -0.8222 | -0.6562 | -0.6442 | -0.6432 | 0.6572 | -0.6982 | -0.5862 | -0.6982 | ||
| Lachnospiraceae | -0.8502 | -0.6532 | -0.7892 | -0.7882 | -0.6132 | 0.7662 | -0.6432 | -0.6292 | -0.6432 | |
| Lactobacillaceae | -0.6162 | -0.6332 | 0.7952 | -0.5292 | ||||||
| Lactobacillales_unclassified | ||||||||||
| Micrococcaceae | 0.6692 | 0.5342 | -0.5282 | 0.4932 | ||||||
| Mollicutes_RF39_fa | -0.6502 | -0.6182 | -0.5902 | -0.6092 | 0.7132 | -0.8572 | -0.7682 | -0.8572 | ||
| Moraxellaceae | -0.6692 | -0.5362 | -0.5572 | -0.5432 | -0.5992 | -0.4732 | -0.5992 | |||
| Muribaculaceae | -0.8162 | -0.7942 | -0.5762 | 0.6932 | -0.6842 | -0.8272 | -0.8462 | -0.8272 | ||
| Pasteurellaceae | ||||||||||
| Prevotellaceae | -0.7052 | 0.6032 | -0.5222 | -0.4862 | ||||||
| Rikenellaceae | -0.6792 | |||||||||
| Saccharimonadaceae | -0.7372 | -0.5592 | -0.6192 | -0.6742 | 0.6562 | -0.7762 | -0.7592 | -0.7762 | ||
| Staphylococcaceae | -0.7342 | -0.6472 | -0.8082 | -0.8382 | 0.7162 | -0.6162 | -0.6792 | -0.6162 | ||
| Streptococcaceae | 0.7902 | 0.7262 | 0.6372 | 0.5952 | -0.6222 | 0.7242 | 0.5152 | |||
1
Variables were evaluated by Spearman's r correlation coefficient, moderate (0.3 < r < 0.6) or strong (0.6 < r < 0.9).
2
Correlation significant at the 0.05 level.
AC: Atherogenic coefficient; CRI: Castelli’s risk index; CVR: Cardiovascular risk; MCP: Monocyte chemoattractant protein; NAFLD: Nonalcoholic fatty liver disease; PAI: Plasminogen activator inhibitor; TIMP: Tissue inhibitor of metalloproteinase.