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. 2022 Jan 7;10(1):12–22. doi: 10.12998/wjcc.v10.i1.12

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Hepatitis B virus life cycle and mechanisms associated with hepatitis B virus reactivation linked to immunosuppressive therapies. APC: Antigen presenting cell; CTL cell: Cytotoxic T lymphocyte cell; cccDNA: Covalently closed circular DNA; IFN: Interferon; TNF-α: Tumour necrosis factor α; JAK: Janus kinase; HBV: Hepatitis B virus.