Table 3.
Cox regression models on overall survival and cumulative incidence of relapse for all patients and according to IS groups.
| All patients | JMDsole | JMD/TKD1 | TKD1sole | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Overall survival | n = 356 | n = 194 | n = 91 | n = 71 | ||||
| TKD1sole (vs JMDsole) | 1.61 (1.10–2.34) | 0.014 | ||||||
| TKD1sole (vs JMD/TKD1) | 2.17 (1.29–3.67) | 0.004 | ||||||
| JMDsole (vs JMD/TKD1) | 1.35 (0.86–2.12) | 0.189 | ||||||
| Midostaurin treatment | 0.79 (0.59–1.06) | 0.120 | 0.56 (0.37–0.84) | 0.005 | 0.94 (0.52–1.71) | 0.835 | 1.12 (0.56–2.24) | 0.741 |
| FLT3-ITD cAR (log2) | 1.07 (0.99–1.15) | 0.093 | 1.18 (1.05–1.33) | 0.006 | 1.12 (0.93–1.34) | 0.239 | 0.97 (0.87–1.09) | 0.641 |
| No of ITDs | 1.13 (0.99–1.28) | 0.076 | 1.29 (1.04–1.60) | 0.022 | 1.10 (0.91–1.32) | 0.317 | 1.01 (0.55–1.85) | 0.983 |
| WBC (log2) | 1.12 (1.03–1.23) | 0.010 | 1.02 (0.91–1.14) | 0.767 | 1.09 (0.89–1.32) | 0.408 | 1.38 (1.09–1.75) | 0.008 |
| Age (10–year difference) | 1.17 (1.02–1.34) | 0.029 | 1.24 (1.03–1.51) | 0.024 | 0.92 (0.68–1.23) | 0.557 | 1.28 (0.96–1.70) | 0.096 |
| NPM1 mutation | 0.58 (0.43–0.78) | <0.001 | 0.47 (0.31–0.72) | <0.001 | 0.69 (0.36–1.30) | 0.248 | 0.57 (0.28–1.15) | 0.115 |
| HCT in CR1 | 0.46 (0.30–0.70) | <0.001 | 0.65 (0.38–1.10) | 0.111 | 0.17 (0.04–0.74) | 0.018 | 0.28 (0.12–0.68) | 0.005 |
| Cumulative Incidence of Relapse | n = 253 | n = 140 | n = 66 | n = 47 | ||||
| TKD1sole (vs JMDsole) | 2.20 (1.34–3.59) | 0.002 | ||||||
| TKD1sole (vs JMD/TKD1) | 1.66 (0.90–3.08) | 0.107 | ||||||
| JMDsole (vs JMD/TKD1) | 0.76 (0.41–1.30) | 0.312 | ||||||
| Midostaurin treatment | 0.80 (0.56–1.15) | 0.222 | 0.57 (0.34–0.96) | 0.036 | 0.87 (0.45–1.69) | 0.686 | 1.93 (0.75–4.97) | 0.171 |
| FLT3-ITD cAR (log2) | 1.16 (1.04–1.29) | 0.007 | 1.45 (1.21–1.73) | <0.001 | 1.05 (0.83–1.32) | 0.649 | 1.02 (0.88–1.21) | 0.776 |
| No of ITDs | 1.05 (0.89–1.24) | 0.538 | 1.43 (1.02–2.02) | 0.040 | 1.02 (0.83–1.26) | 0.846 | 0.69 (0.30–1.58) | 0.379 |
| WBC (log2) | 1.18 (1.06–1.31) | 0.003 | 1.16 (0.99–1.35) | 0.062 | 1.18 (0.95–1.47) | 0.139 | 1.33 (1.04–1.70) | 0.021 |
| Age (10-year difference) | 1.00 (0.84–1.18) | 0.982 | 1.04 (0.81–1.33) | 0.766 | 0.98 (0.70–1.37) | 0.908 | 1.02 (0.70–1.50) | 0.904 |
| NPM1 mutation | 0.67 (0.45–0.98) | 0.037 | 0.46(0.27–0.78) | 0.004 | 0.81(0.41–1.62) | 0.555 | 0.91(0.30–2.47) | 0.858 |
| HCT in CR1 | 0.42 (0.26–0.69) | <0.001 | 0.40(0.20–0.80) | 0.010 | 0.68(0.27–1.70) | 0.409 | 0.19(0.06–0.57) | 0.003 |