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. 2021 Jun 15;36(1):80–89. doi: 10.1038/s41375-021-01316-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The DNAm levels at four AML-associated CpGs (cg15289427, cg22797031, cg19586199, and cg27630153) were analyzed in Illumina Human Methylation 450k BeadChip datasets of controls, AML, and other hematologic malignancies. b Alternatively, DNAm was analyzed with bisulfite amplicon sequencing (BA-seq) in controls (n = 62), AML at first diagnosis (n = 48), and follow-up samples that were either classified MRD positive (n = 28) or MRD negative (n = 17) based on NPM1^mut. c DNAm at the four AML-associated CpGs is combined into an AML-score. The cutoff of 99.5% percentile of the healthy samples is shown by the blue line.