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. 2021 Jun 15;36(1):80–89. doi: 10.1038/s41375-021-01316-z

Fig. 4. Aberrant DNAm is symmetric between both alleles.

Fig. 4

The figure depicts DNAm patterns of a patient (#56) with SNPs rs115701567 at chr16:88844998 (cg27630153) and rs917911737 at chr19:14225172 (cg19586199). These SNPs were used to split BA-seq reads of the different alleles. Particularly at first diagnosis the amplicon revealed aberrant DNAm, which normalized during therapy (reflected by lower MRD burden). Upon relapse, both alleles revealed aberrant DNAm patterns. Notably, DNAm patterns were apparently always synchronized between alleles.