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Decreased Teff Cells and Increased Regulatory T cells (Tregs) in CDLNs after IL-38 treatment. (A–H) The proportions of CD4+IL-17A+ A and B, CD4+IL-22+ C and D, CD4+IFN-γ+ (E, F), and CD4+CD25+Foxp3+ (G, H) cells on the gate of CD4+ cells in CDLNs after immunization at day 14 in EAU mice and IL-38-treated mice (n = 6). Data shown as mean ± SD from three independent experiments. Data were analyzed using unpaired two-tailed Student t-tests, ****P < 0.0001.
