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. 2021 Dec 22;12:802858. doi: 10.3389/fimmu.2021.802858

Figure 1.

Figure 1

Characterization of SARS-CoV-2-specific antibodies and T cell responses in individuals before and after vaccination. (A) SARS-CoV-2 S-RBD IgG and NAb levels in serum before and after vaccination. The dotted line indicates the cut-off value of the antibody. (B) The antibody positivity for SARS-CoV-2 S-RBD IgG and NAb before and after vaccination. (C) The magnitude and response rate of overall cytokine responses of CD4+ T cells against S, N, and M of SARS-CoV-2 in the participants before and after the first and second vaccination. (D) The magnitude and response rate of overall cytokine responses of CD8+ T cells against S, N, and M of SARS-CoV-2 in the participants pre- and post-vaccination. (E)The breadth of CD4+ and CD8+ T cell responses before and after the first and second vaccination. Baseline: before vaccination; 1st: after the first vaccination; 2nd: after the second vaccination. Each symbol represents an individual donor with a line indicating the median of each group. One-way ANOVA followed by Turkey’s multiple comparisons test was used to test the statistical significance of data shown in (A), (C, D). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.