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. 2021 Dec 22;12:802858. doi: 10.3389/fimmu.2021.802858

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Copyright © 2021 Li, Xiang, Liang, Deng, Wang, Feng, Quan, Wang, Li, Lu, Yang, Wang, Zelinskyy, Trilling, Sutter, Lu, Dittmer, Yang, Zheng and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in SARS-CoV-2-specific humoral and cellular immune responses between male and female vaccinees. (A) Comparison of the SARS-CoV-2 S-RBD IgG and NAb levels in serum after the second vaccination between male and female vaccinees. The dotted line indicates the cut-off value of the antibody. (B) Comparison of the magnitude of CD4+ and CD8+ T cell responses against S, N, and M of SARS-CoV-2 between male and female vaccinees. (C) Comparison of the breadth of CD4+ and CD8+ T cell responses between male and female vaccinees. Each symbol represents an individual donor with a line indicating the median of each group. Mann Whitney U test was used to test the statistical significance of data shown in (A, B). **P < 0.01; ***P < 0.001.