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. 2021 Dec 22;12:761382. doi: 10.3389/fimmu.2021.761382

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Copyright © 2021 Supriya, Gao, Gu and Baker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of Naive T (T0) cells differentiation in (A) T helper 1 (Th1) cells due to the surrounding microenvironment of IL-12 and further secretes IL-2 and IFN-ϒ and activates macrophage and causes inflammation, (B) T helper 2 (Th2) cells due to the surrounding microenvironment of IL-4 and further secretes IL-4, IL-5, IL-13 and activates eosinophil and B cells, (C) T helper 17 (Th17) cells due to the surrounding microenvironment of IL-6 and TGF-β and further secretes IL-17, IL-22 to recruit neutrophils and causes inflammation, (D) T regulatory (Treg) cells that secretes IL-10, TGF-β and suppresses immune response, (E) Follicular helper T (TFH) cells and secretes IL-21, and guide B cells to produce antibodies. IL is interleukins, TGF-β is Transforming growth factor-β and a B cell is B lymphocytes.