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. 2021 Dec 22;8:792782. doi: 10.3389/fmed.2021.792782

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Copyright © 2021 Shen, Cheng, Yu, Li, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of log-transformed urinary β2-microglobulin (β2-MG) (A) and log-transformed urinary retinol-binding protein (RBP) (B) levels with the composite renal outcome. Three knots at the 25th, 50th, and 75th percentiles were used to model restricted cubic splines. Solid lines are multivariable adjusted hazard ratios, with dashed lines showing 95% CIs for the spline model (reference: log β2-MG 1.75 mg/mol Cr and log RBP 2.00 mg/mol Cr). Models were adjusted for age, sex, mean arterial pressure (MAP), log-transformed proteinuria, serum creatinine, and the Oxford classification (MEST-C scores).