Table 2:
Changes in evoked mechanical sensation, evoked thermal sensation, and Neuropathic Pain Symptom Inventory (NPSI) questionnaire descriptors at baseline and 60 minutes after infusion initiation (n = 31). Paired samples t-test utilized to compare groups.
| Placebo | Lidocaine | Lidocaine minus placebo | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pre infusion | 60 minutes | Change (60 min minus pre infusion) | Pre infusion | 60 minutes | Change (60 min minus pre infusion) | Difference | 95% CI | P value | |
| Neuropathic Pain Symptom Inventory subscores | |||||||||
| Burning pain, mean (SD) | 2.90 (2.64) | 1.65 (2.75) | −1.26 (2.44) | 3.00 (2.78) | 1.00 (1.79) | −2.00 (2.25) | −0.74 (3.11) | −1.88 to 0.40 | 0.19 |
| Paroxysmal pain, mean (SD) | 1.15 (1.69) | 0.84 (1.70) | −0.31 (1.15) | 2.00 (2.44) | 0.85 (2.14) | −1.15 (1.92) | −0.84 (2.13) | −1.62 to −0.56 | 0.04 |
| Paresthesia/dysesthesia, mean (SD) | 3.02 (2.66) | 2.13 (2.61) | −0.89 (1.60) | 3.94 (2.76) | 1.76 (2.25) | −2.18 (2.07) | −1.29 (2.01) | −2.03 to −0.55 | 0.001 |
| Evoked mechanical and thermal sensation | |||||||||
| Cold intensity, mean (SD) | 2.74 (2.16) | 3.45 (1.96) | 0.71 (1.59) | 3.00 (2.20) | 2.87 (2.31) | −0.13 (1.26) | −0.84 (2.16) | −1.63 to −0.05 | 0.04 |
| Heat intensity, mean (SD) | 1.87 (1.82) | 1.97 (1.83) | 0.10 (1.37) | 1.87 (1.82) | 1.77 (1.69) | −0.10 (1.19) | −0.19 (1.70) | −0.82 to 0.43 | 0.53 |
| Brush intensity, mean (SD) | 3.83 (1.73) | 3.48 (1.98) | −0.35 (1.97) | 3.55 (1.84) | 3.42 (1.88) | −0.13 (1.45) | 0.23 (2.31) | −0.62 to 1.07 | 0.59 |
| Pinprick intensity, mean (SD) | 3.16 (2.48) | 3.35 (2.51) | 0.19 (2.14) | 3.84 (2.53) | 3.19 (2.68) | −0.65 (1.96) | −0.84 (2.57) | −1.78 to 0.10 | 0.08 |