FIGURE 1.

(A) Cartoon depiction highlighting the major role of SHANKs in the postsynaptic structure of glutamatergic synapses, linking proteins across the depth of the PSD from the actin cytoskeleton to surface AMPA and NMDA receptors. (B) ASD-associated synaptic changes in Shank rodent models known to occur in the prefrontal cortex, striatum, hippocampus, and cerebellum. (Left) Brain regions highlighted in this minireview where Shankopathies have been most studied. (Right) Cartoon depictions of some of the synaptic changes occurring in each region. Created with Biorender.