Table 3.
Concentrations of cytokines in serum and saliva of patients presenting with oral ulceration (Mouth Active (BD-MA)) or without (Mouth Quiet (BD-MQ)) oral ulceration involvement.
| Cytokines | Group | Serum† | Saliva | p-values* | ||
|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | |||
| IL-1β | HC | 0.01 | 0.01, 0.01 | 752.4 | 447.1, 1775 | |
| BD-MQ | 0.01 | 0.01, 48.8 | 1168 | 933.7, 2233 | 0.22 | |
| BD-MA | 0.01 | 0.01, 85.2 | 1512 | 602.6, 3068 | 0.24 | |
| BD-ALL | 0.01 | 0.01, 36.8 | 1489 | 727.4, 2383 | 0.15 | |
| IL-2 | HC | 20.3 | 0.01, 185.1 | 187.8 | 125.4, 249.8 | |
| BD-MQ | 0.01 | 0.01, 175.6 | 190.6 | 138.1, 238 | 0.85 | |
| BD-MA | 66.9 | 20.3, 96.8 | 173.6 | 137.7, 246.3 | 0.68 | |
| BD-ALL | 40.6 | 0.01, 71.3 | 176.4 | 139.6, 232.4 | 0.72 | |
| IL-4 | HC | 0.01 | 0.01, 0.01 | 94.8 | 40.5, 124.7 | |
| BD-MQ | 0.01 | 0.01, 32.7 | 82.4 | 47, 116.6 | 0.74 | |
| BD-MA | 0.01 | 0.01, 51.9 | 93.1 | 67.6, 101.7 | 0.95 | |
| BD-ALL | 0.01 | 0.01, 51.9 | 91.4 | 53, 102.5 | 0.80 | |
| IL-5 | HC | 0.01 | 0.01, 21.2 | 85.9 | 36.9, 119.1 | |
| BD-MQ | 0.01 | 0.01, 8.2 | 60.8 | 50.8, 114.2 | 0.59 | |
| BD-MA | 0.01 | 0.01, 13.5 | 95.2 | 46.9, 126.3 | 0.65 | |
| BD-ALL | 0.01 | 0.01, 13.5 | 67.8 | 51.3, 117.5 | 0.94 | |
| IL-6 | HC | 0.01 | 0.01, 0.01 | 9.5 | 4.9, 26.3 | |
| BD-MQ | 0.01 | 0.01, 2.1 | 10.4 | 0, 18.9 | 0.69 | |
| BD-MA | 0.01 | 0.01, 0.01 | 63.9 | 13, 103.2 | 0.04 | |
| BD-ALL | 0.01 | 0.01, 0.01 | 17.1 | 0.01, 91.3 | 0.41 | |
| IL-8 | HC | 127.4 | 25.1, 975.5 | 410.3 | 237.5, 966.9 | |
| BD-MQ | 135.8 | 65.9, 476.8 | 572.8 | 342.4, 1787 | 0.55 | |
| BD-MA | 363.9 | 44.5, 601.5 | 604.3 | 325.4, 1881 | 0.54 | |
| BD-ALL | 145 | 72.6, 535 | 588.5 | 329.6, 1804 | 0.47 | |
| IL-10 | HC | 0.01 | 0.01, 12.8 | 50.5 | 29.8, 78.4 | |
| BD-MQ | 6 | 0.01, 41.4 | 75.7 | 26.9, 142.9 | 0.59 | |
| BD-MA | 13 | 0.01, 17.3 | 65.9 | 28, 160 | 0.67 | |
| BD-ALL | 11.9 | 0.01, 16.5 | 70.8 | 28.54 | 0.57 | |
| Il-12p70 | HC | 0.01 | 0.01, 3.9 | 116.5 | 57.8, 203.7 | |
| BD-MQ | 0.01 | 0.01, 0.6 | 82 | 5, 161.4 | 0.39 | |
| BD-MA | 0.01 | 0.01, 21.1 | 94.8 | 34.7, 214.3 | 0.84 | |
| BD-ALL | 0.01 | 0.01, 0.01 | 88.4 | 23.4, 182.5 | 0.50 | |
| IL-17A | HC | 0.01 | 0.01, 5.8 | 24.4 | 1.5, 70 | |
| BD-MQ | 0.01 | 0.01, 16.1 | 27.2 | 12.7, 48 | 0.74 | |
| BD-MA | 0.01 | 0.01, 0.01 | 21 | 10.7, 59.2 | 0.86 | |
| BD-ALL | 0.01 | 0.01, 0.01 | 25.7 | 14, 55.2 | 0.75 | |
| IFN-γ | HC | 0.01 | 0.01, 0.01 | 0.01 | 0.01, 98.8 | |
| BD-MQ | 0.01 | 0.01, 0.01 | 0.01 | 0.01, 89.9 | 1 | |
| BD-MA | 0.01 | 0.01, 0.01 | 0.01 | 0.01, 147.8 | 0.75 | |
| BD-ALL | 0.01 | 0.01, 0.01 | 0.01 | 0.01, 93.5 | 0.86 | |
| TNF-α | HC | 0.01 | 4.6, 24.6 | 40.2 | 24.4, 64.5 | |
| BD-MQ | 1.3 | 23.9, 100.9 | 42.2 | 18.7, 81.5 | 0.96 | |
| BD-MA | 1.2 | 3.6, 13 | 59.0 | 40.4, 123.9 | 0.10 | |
| BD-ALL | 5.5 | 1.7, 24.4 | 55.8 | 25.4, 83.3 | 0.36 | |
| TNF-β | HC | 0.01 | 0.01, 32.1 | 87.4 | 33.3, 209 | |
| BD-MQ | 0.01 | 0.01, 35.6 | 53.9 | 38.3, 170.5 | 0.69 | |
| BD-MA | 0.01 | 0.01, 20.1 | 114.8 | 47.4, 163.2 | 0.74 | |
| BD-ALL | 0.01 | 0.01, 0.01 | 92.9 | 38.8, 169.5 | 0.96 | |
†Serum concentrations showed no significant differences between groups.
*p-value when compared with HC saliva. Significant values in bold.
Serum HC N=10, BD-MQ N=10, BD-MA N=9, BD-ALL N=19. Non-normalized saliva HC N=10, BD-MQ N=11, BD-MA N=9, BD-ALL N=20. Median concentrations with interquartile ranges (IQR) are shown. Cytokines below the lower levels limits of detection were considered not detectable and therefore arbitrarily assigned concentrations of 0.01 pg/ml. p values are given for comparisons between HC and BD subgroups.