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. 2021 Oct 27;126(1):109–119. doi: 10.1038/s41416-021-01579-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Expression levels of CCAT1 RNA and KLF5 mRNA in KLF5 knockdown cells. The relative value is calculated by the expression level of the si-negative control transfected cells (siNC). *P < 0.01. b Expression levels of KLF5 mRNA and CCAT1 RNA in ML264-treated cells (HT29, SW48). ML264 (10 µM) was treated for 24 h. The relative value is calculated by the expression level of DMSO-treated control cells. *P < 0.01. c The binding of the KLF5, BRD4, MED1 and RAD21 proteins to the CCAT1 TSS region in the HT29 (top) and SW48 (bottom) cell lines analysed by ChIP-qPCR. The fold enrichment normalised to the value of the IgG control is shown. *P < 0.01. d Expression level of CCAT1 RNA in five heterodeletion mutants of the KLF5 enhancer. The relative value is calculated by the expression level of the parental cells. The average value of five heterodeletion mutants is also shown. *P < 0.01.