Table 2.
Univariate and multivariate analyses for the association between SNPs and tumour response.
| SNP/genetic model | Oxaliplatin cohort | Irinotecan cohort | ||
|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |
| Pa | Pb | Pa | Pb | |
| TIMELESS rs2291739 | ||||
| Dominant | 0.64 | 0.85 | 0.90 | 0.89 |
| Recessive | 0.39 | 0.84 | 0.79 | 0.29 |
| TIPIN rs3759786 | ||||
| Dominant | 0.97 | 0.90 | 0.80 | 0.28 |
| Recessive | NA | NA | NA | NA |
| TIPIN rs8035497 | ||||
| Dominant | 0.63 | 0.63 | 0.87 | 0.61 |
| Recessive | 0.52 | 0.55 | 0.43 | 0.21 |
| TIPIN rs11071888 | ||||
| Dominant | 0.47 | 0.77 | 0.22 | 0.56 |
| Recessive | 0.63 | 0.92 | 0.56 | 0.96 |
| TIPIN rs28593577 | ||||
| Dominant | 0.71 | 0.91 | 0.96 | 0.83 |
| Recessive | 1.00 | 0.65 | 0.70 | 0.30 |
| TIPIN rs11637949 | ||||
| Dominant | 0.61 | 0.23 | 0.73 | 0.68 |
| Recessive | 0.06 | 0.04 | 0.83 | 0.56 |
| TIPIN rs6494568 | ||||
| Dominant | 0.72 | 0.25 | 0.74 | 0.50 |
| Recessive | NA | NA | NA | NA |
| TIPIN rs12323975 | ||||
| Dominant | 0.79 | 0.79 | 0.56 | 0.58 |
| Recessive | NA | NA | NA | NA |
Significant values are indicated in bold characters. TIPIN rs3759786, TIPIN rs6494568, and TIPIN rs12323975 were not assessed with recessive genetic model because there were no patients having homozygous genotype of the recessive allele in these SNPs.
NA not assessed, SNP single nucleotide polymorphism.
aP-values were based on likelihood ratio test.
bP-values were based on Wald test in the multivariate model.