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. 2021 Oct 23;126(1):72–78. doi: 10.1038/s41416-021-01592-7

Table 4.

Univariate and multivariate analyses for the association between SNPs and OS.

SNP/genetic model Oxaliplatin cohort Irinotecan cohort
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95% CI) Pa HR (95% CI) Pb HR (95% CI) Pa HR (95% CI) Pb
TIMELESS rs2291739
 Dominant 1.03 (0.64–1.66) 0.90 1.41 (0.76–2.60) 0.27 1.32 (0.70–2.48) 0.39 1.47 (0.73–2.96) 0.27
 Recessive 0.63 (0.34–1.14) 0.12 0.83 (0.36–1.94) 0.66 2.01 (1.19–3.41) 0.008 3.06 (1.49–6.25) 0.004
TIPIN rs3759786
 Dominant 0.78 (0.42–1.45) 0.44 0.68 (0.32–1.42) 0.28 0.80 (0.42–1.50) 0.48 1.03 (0.47–2.27) 0.94
 Recessive NA NA NA NA NA NA NA NA
TIPIN rs8035497
 Dominant 1.13 (0.73–1.75) 0.59 1.41 (0.81–2.43) 0.22 0.59 (0.35–1.01) 0.05 0.53 (0.26–1.10) 0.08
 Recessive 1.96 (1.02–3.75) 0.04 2.02 (0.93–4.42) 0.09 0.21 (0.03–1.52) 0.09 0.20 (0.02–1.57) 0.06
TIPIN rs11071888
 Dominant 0.64 (0.39–1.06) 0.08 0.63 (0.32–1.24) 0.17 1.32 (0.80–2.20) 0.28 0.85 (0.41–1.76) 0.66
 Recessive 0.46 (0.06–3.30) 0.43 0.42 (0.05–3.57) 0.38 2.01 (0.73–5.58) 0.17 0.62 (0.15–2.54) 0.50
TIPIN rs28593577
 Dominant 0.87 (0.56–1.36) 0.54 1.00 (0.58–1.75) 0.99 0.78 (0.45–1.35) 0.37 0.64 (0.30–1.35) 0.23
 Recessive 1.52 (0.69–3.33) 0.29 1.42 (0.59–3.40) 0.45 0.24 (0.03–1.74) 0.13 0.21 (0.03–1.67) 0.07
TIPIN rs11637949
 Dominant 1.04 (0.66–1.64) 0.86 1.01 (0.58–1.76) 0.96 1.95 (1.17–3.24) 0.009 1.81 (0.93–3.51) 0.08
 Recessive 1.87 (0.81–4.32) 0.14 2.16 (0.84–5.55) 0.14 1.38 (0.59–3.21) 0.45 1.10 (0.43–2.82) 0.84
TIPIN rs6494568
 Dominant 1.39 (0.83–2.33) 0.21 0.99 (0.47–2.07) 0.98 0.92 (0.48–1.76) 0.79 2.18 (0.91–5.19) 0.09
 Recessive NA NA NA NA NA NA NA NA
TIPIN rs12323975
 Dominant 0.70 (0.38–1.29) 0.25 0.67 (0.30–1.46) 0.29 1.21 (0.61–2.39) 0.58 0.54 (0.19–1.49) 0.21
 Recessive NA NA NA NA NA NA NA NA

Significant values are indicated in bold characters. TIPIN rs3759786, TIPIN rs6494568, and TIPIN rs12323975 were not assessed with recessive genetic model because there were no patients having homozygous genotype of the recessive allele in these SNPs.

CI confidence interval, HR hazard ratio, NA not assessed, OS overall survival, SNP single nucleotide polymorphism.

aP-values were based on log-rank test.

bP-values were based on Wald test in the multivariate Cox proportional hazards regression model.