Table 5.
Treatment-by-SNP interaction test.
| SNP | Dominant genetic model | Recessive genetic model | ||||
|---|---|---|---|---|---|---|
| TR | PFS | OS | TR | PFS | OS | |
| Interaction P | Interaction P | Interaction P | Interaction P | Interaction P | Interaction P | |
| TIMELESS rs2291739 | 0.73 | 0.86 | 0.90 | 0.44 | 0.04 | 0.007 |
| TIPIN rs3759786 | 0.54 | 0.73 | 0.53 | NA | NA | NA |
| TIPIN rs8035497 | 0.34 | 0.07 | 0.02 | 0.87 | 0.55 | 0.01 |
| TIPIN rs11071888 | 0.90 | 0.28 | 0.49 | 0.91 | 0.08 | 0.67 |
| TIPIN rs28593577 | 0.66 | 0.28 | 0.24 | 0.55 | 0.45 | 0.04 |
| TIPIN rs11637949 | 0.61 | 0.99 | 0.15 | 0.12 | 0.73 | 0.49 |
| TIPIN rs6494568 | 0.65 | 0.42 | 0.27 | NA | NA | NA |
| TIPIN rs12323975 | 0.65 | 0.40 | 1.00 | NA | NA | NA |
Significant values are indicated in bold characters. TIPIN rs3759786, TIPIN rs6494568, and TIPIN rs12323975 were not assessed with recessive genetic model because there were no patients having homozygous genotype of the recessive allele in these SNPs.
NA not assessed, OS overall survival, PFS progression-free survival, SNP single nucleotide polymorphism, TR tumour response.