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. 2021 Dec 22;12:772160. doi: 10.3389/fimmu.2021.772160

Figure 3.

Figure 3

Detailed transcriptome differences in oncogenes, tumor suppressor genes, genes involved in cell proliferation, and genes coding for the cyclin dependent kinase inhibitors in HMECs infected with low-risk and high-risk HCMV strains. (A) Assessment of the individual oncogenes expression including MYC, FOS, KRAS, JUN, and E2F1. (B) Assessment of the individual expression of tumor suppressor genes: TP53, TP73, SMAD4, VHL, RB, TSC1, and MDM2. (C) Assessment of the individual expression of genes involved in cell proliferation such as STAT3, CCDN1, and MKI67. (D) Assessment of the individual expression of genes coding for the cyclin-dependent kinase inhibitors: CDKN1A, CDKN2A, CDKN2B, and CDKN3. The gene expression was measured in HMECs infected with HCMV-BL, HCMV-TB40/E, HCMV-FS and HCMV-KM (MOI = 1) and compared to uninfected HMECs. Results represent mean ± SD of three independent experiments. p-values were determined by Wilcoxon test. *p-value < 0.05.