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. 2021 Dec 22;12:772160. doi: 10.3389/fimmu.2021.772160

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Copyright © 2021 Haidar Ahmad, Pasquereau, El Baba, Nehme, Lewandowski and Herbein

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome differences in genes involved in cell survival, DNA reparation, cell adhesion, angiogenesis, and EMT markers in HMECs infected with low-risk and high-risk HCMV strains. Up- and downregulation of the expression of genes involved in (A) cell survival such as AKT and REL, (B) in DNA reparation (ATM and MLH), (C) in cell adhesion such as E-cadherin (CDH1) and beta-catenin (CTNNB1), (D) in angiogenesis (S100A4 and EGF) and (E) of the EMT markers (TGFB1 and SRC). The gene expression was measured in HMECs infected with HCMV-BL, HCMV-TB40/E, HCMV-FS and HCMV-KM (MOI = 1) and compared to uninfected HMECs. Data are represented as mean ± SD of three independent experiments. p-values were determined by Wilcoxon test. *p-value < 0.05.