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. 2021 Dec 22;12:772160. doi: 10.3389/fimmu.2021.772160

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Copyright © 2021 Haidar Ahmad, Pasquereau, El Baba, Nehme, Lewandowski and Herbein

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A hypothetical model to summarize the transcriptome differences between low-risk and high-risk HCMV strains based on the modulation of cellular pathways involved in oncogenesis. In contrast to the low-risk HCMV strains (e.g. HCMV-FS, HCMV-KM and HCMV-TB40/E), the high-risk HCMV strains (e.g. HCMV-DB and HCMV-BL) strongly upregulate the expression of oncogenes, cell proliferation genes, genes involved in cell survival and EMT genes, thereby they might favor the initiation and/or the progression of basal breast tumors with poor prognosis.