TABLE 2.
Functional parameters.
| Parameters | All patients (n = 107) | CTD-ILD (n = 63) | IPAF (n = 44) | p-value |
|---|---|---|---|---|
| Lung function | – | – | – | – |
| FEV1/FVC | 0.84 ± 0.08 | 0.84 ± 0.06 | 0.82 ± 0.10 | 0.287 |
| FVC (L) | 2.50 ± 0.86 | 2.49 ± 0.89 | 2.52 ± 0.83 | 0.951 |
| FVC (%) | 84.41 ± 23.86 | 85.51 ± 26.93 | 82.82 ± 18.72 | 0.577 |
| FEV1 (L) | 2.08 ± 0.72 | 2.09 ± 0.73 | 2.07 ± 0.71 | 0.819 |
| FEV1 (%) | 85.64 ± 24.67 | 86.82 ± 26.26 | 83.93 ± 22.36 | 0.562 |
| TLC (L) | 4.31 ± 1.43 | 4.39 ± 1.54 | 4.19 ± 1.26 | 0.683 |
| TLC (%) | 80.64 ± 24.82 | 83.86 ± 26.54 | 76.13 ± 21.73 | 0.133 |
| Diffusion parameters | – | – | – | – |
| DLCO (mmol/min/kPa) | 5.52 ± 1.87 | 5.55 ± 1.84 | 5.47 ± 1.94 | 0.899 |
| DLCO (%) | 70.92 ± 20.88 | 70.53 ± 20.07 | 71.48 ± 22.21 | 0.823 |
| KLCO (mmol/min/kPa/l) | 1.26 ± 0.38 | 1.27 ± 0.37 | 1.24 ± 0.39 | 0.943 |
| KLCO (%) | 66.19 ± 18.54 | 65.25 ± 18.12 | 67.50 ± 19.26 | 0.551 |
| BGA | – | – | – | – |
| pH | 7.42 ± 0.04 | 7.43 ± 0.05 | 7.42 ± 0.02 | 0.204 |
| pCO2 | 40.10 ± 11.13 | 41.13 ± 11.87 | 38.86 ± 10.19 | 0.859 |
| pO2 | 66.69 ± 11.82 | 65.63 ± 13.85 | 67.96 ± 8.80 | 0.859 |
| 6MWT | – | – | – | – |
| Distance (m) | 400.73 ± 108.15 | 403.45 ± 120.96 | 397.61 ± 93.02 | 0.822 |
| SpO2 baseline | 94.51 ± 4.15 | 95.00 ± 3.35 | 93.91 ± 4.94 | 0.490 |
| SpO2 post-exercise | 90.12 ± 8.97 | 90.69 ± 6.74 | 89.47 ± 11.06 | 0.223 |
| Pulse baseline | 84.05 ± 14.50 | 84.75 ± 12.88 | 83.24 ± 16.37 | 0.658 |
| Pulse post-exercise | 106.71 ± 19.83 | 109.84 ± 19.56 | 103.21 ± 19.82 | 0.158 |
| Borg scale baseline | 2.01 ± 11.46 | 3.23 ± 15.42 | 0.55 ± 1.25 | 0.253 |
| Borg scale post-exercise | 4.05 ± 11.05 | 5.33 ± 14.86 | 2.56 ± 2.15 | 0.223 |
CTD-ILD, connective tissue disease-associated interstitial lung disease; IPAF, interstitial pneumonia with autoimmune features; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; TLC, total lung capacity; DLCO, diffusing capacity for carbon monoxide; KLCO, transfer coefficient of the lung for carbon monoxide; BGA, blood gas analysis; 6MWT, 6-min walk test.