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. 2021 Dec 22;11:778132. doi: 10.3389/fonc.2021.778132

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Copyright © 2021 Ruan, Gu, Xia, Gong, Zhou, Chen and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircMETTL3 serves as a sponge for miR-34c-3p. (A) Two dual-luciferase reporter vectors containing wild-type circMETTL3 (circMETTL3-WT) or site mutant circMETTL3 (circMETTL3-Mut) were constructed. (B) Dual-luciferase assay was used to evaluate the targeting of miR-34c-3p to wild-type circMETTL3. (C) The over-expression of circMETTL3 was evaluated by real-time PCR in the indicated TNBC cells. (D) The level of METTL3 mRNA was evaluated by real-time PCR in the indicated TNBC cells. (E) The level of circMETTL3 in TNBC tissues and paired normal tissues were detected by real-time PCR (n=30). (F) The level of circMETTL3 in 10 breast cell lines were detected by real-time PCR. *P < 0.05, **P < 0.01 and ***P < 0.001 versus indicated group.