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. 2021 Dec 22;11:778132. doi: 10.3389/fonc.2021.778132

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Copyright © 2021 Ruan, Gu, Xia, Gong, Zhou, Chen and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Over-expression of CircMETTL3 inhibits proliferation, migration, and invasion via miR-34c-3p/METTL3 signaling pathway in vitro. (A) The level of METTL3 mRNA in the circMETTL3 over-expression with or without METTL3 knock-down TNBC cells was evaluated by real-time PCR. (B) The cell viability of circMETTL3 over-expression with or without METTL3 knock-down TNBC cells was detected by CCK-8 assay. (C) The migration ability of circMETTL3 over-expression with or without METTL3 knock-down TNBC cells was detected by wound healing assay. (D) The invasion ability of circMETTL3 over-expression with or without METTL3 knock-down TNBC cells was detected by transwell assay. *P < 0.05 versus indicated group.