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. 2021 Dec 22;11:778132. doi: 10.3389/fonc.2021.778132

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Copyright © 2021 Ruan, Gu, Xia, Gong, Zhou, Chen and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Over-expression of CircMETTL3 inhibits the tumor growth and metastasis of MDA-MB-231 cells via miR-34c-3p/METTL3 signaling pathway in vivo. (A) In vivo xenograft models were performed and representative image of generated tumors were shown. (B) Tumor volume was monitored every 5 days for 30 days; (C) The tumor weight was analyzed after the mice was sacrificed; (D) In vivo xenograft models were performed and representative image of lung metastasis were shown; (E) The number of lung metastasis were counted. *P < 0.05 versus indicated group.