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. 2021 Nov 1;126(1):100–108. doi: 10.1038/s41416-021-01607-3

Fig. 5. TIM3-associated CD8+ T cell dysfunction indicates inferior chemotherapeutic responsiveness in gastric cancer.

Fig. 5

a Kaplan–Meier curves of overall survival (left panel) and disease-free survival (right panel) based on the combination of CD8+ T cells and tumour-infiltrating TIM3+ cells in all patients. Log-rank test was utilised for the analysis. b Multivariate Cox analysis of overall survival and disease-free survival was performed based on CD8+ T cell infiltration in TIM3 low and high subgroups, with ACT treatment or not. HR hazard ratio, CI confidence interval. P values less than 0.05 were shown in bold.