Table 1.
Clinical Characteristics of Study Subjects
| AE-ILD; No Transplant (n = 28) | AE-ILD; Transplant (n=25) | Stable ILD; Transplant (n=67) | p value | ||
|---|---|---|---|---|---|
| Median age/years (IQR) | 63 (58–68) | 62 (56–65) | 61 (55–66) | 0.40 | |
| Male sex | 21 (75%) | 15 (60%) | 52 (78%) | 0.23 | |
| Diagnosis | 0.04 | ||||
| Idiopathic pulmonary fibrosis | 0 (0%) | 2 (8%) | 13 (19%) | ||
| IPAF / CTD | 9 (32%) | 8 (32%) | 19 (28%) | ||
| Hypersensitivity pneumonitis | 0 (0%) | 3 (12%) | 11 (16%) | ||
| Unclassifiable | 17 (60%) | 10 (40%) | 22 (33%) | ||
| Other a | 2 (8%) | 2 (8%) | 2 (3%) | ||
| Smoking history (%) | 0.65 | ||||
| Ever | 18 (64%) | 17 (68%) | 39 (58%) | ||
| Never | 10 (36%) | 8 (32%) | 28 (42%) | ||
| Lung Function (median & IQR) | |||||
| Percent predicted FVC (IQR) | 57 (37–68) | 47 (39–63) | 44 (37–53) | 0.199 | |
| Percent predicted DLCO (IQR) | 32 (23–43) | 24 (18–28) | 27 (20–32) | 0.11 | |
| Comorbidities (%) | |||||
| Pulmonary hypertension | 3 (11%) | 14 (56%) | 37 (55%) | 0.0002 | |
| Sleep apnoea | 3 (11%) | 1 (4%) | 7 (10%) | 0.60 | |
| Coronary artery disease | 7 (25%) | 3 (12%) | 10 (15%) | 0.38 | |
| Gastroesphageal reflux disease | 3 (11%) | 7 (28%) | 17 (25%) | 0.22 | |
| BMI (kg/m2; median and IQR) | 28 (25–32) | 25 (23–28) | 28 (26–30) | 0.0027 | |
| Outpatient immunosuppression prior to transplantation | |||||
| Prednisone | 12 (43%) | 9 (36%) | 24 (36%) | 0.8 | |
| Mycophenolate | 6 (21%) | 3 (12%) | 21 (31%) | 0.14 | |
| Azathioprine | 2 (7%) | 0 (0%) | 6 (9%) | 0.31 | |
| Outpatient antifibrotic therapy | |||||
| Pirfenidone | 2 (7%) | 0 (0%) | 11 (16%) | 0.06 | |
| Nintedanib | 4 (14%) | 4 (16%) | 7 (10%) | 0.73 | |
| Median GAP score (IQR) | 4 (4–6) | 5 (4–6) | 5 (5–6) | 0.047 | |
Abbreviations: AE-ILD, acute exacerbation of interstitial lung disease; IPAF/CTD, interstitial pneumonia with autoimmune features/connective tissue disease associated lung disease; FVC, forced vital capacity; DLCO, diffusing capacity of the lung for carbon monoxide; BMI, body mass index; GAP (gender/age/physiology) Score.
a
Other diagnoses included inflammatory bowel disease-related ILD (1), non-specific interstitial pneumonia (1), Hermansky-Pudlak syndrome (2), pneumoconiosis (1), nitrofurantoin-induced lung disease (1), desquamative interstitial pneumonia (1)