Table 2.
Transplant and Post-Transplant Outcomes Data
| AE-ILD; Transplant (n = 25) | Stable ILD; Transplant (n = 67) | p value | ||
|---|---|---|---|---|
| Median LAS (IQR) | 82 (61–87) | 42 (38–50) | <0.0001 | |
| Median time on waiting list (IQR) | 10 (4–23) | 22 (10–44) | 0.0008 | |
| Type of Transplant (%) | 0.10 | |||
| Single | 0 (0%) | 9 (13%) | ||
| Bilateral | 25 (100%) | 58 (87%) | ||
| Intra-operative ECMO or CPB | 24 (96%) | 62 (93%) | >0.99 | |
| Post-operative ECMO at 24hrs | 5 (20%) | 6 (9%) | 0.16 | |
| Reintubation after surgery (%) | 3 (12%) | 8 (12%) | >0.99 | |
| Tracheostomy | 4 (16%) | 10 (15%) | >0.99 | |
| Median duration of mechanical ventilation/days (IQR) | 2 (1–7.75) | 1 (1–2) | 0.16 | |
| Median hospital stay after transplantation/days (IQR) | 24.5 (16–29) | 18 (12–30) | 0.125 | |
| Any PGD (%) at 0 hrs * | 21 (88%) | 38 (59%) | 0.01 | |
| Any PGD (%) at 24 hrs * | 16 (67%) | 32 (49%) | 0.15 | |
| Any PGD (%) at 48 hrs * | 12 (50%) | 27 (41%) | 0.47 | |
| Any PGD (%) at 72 hrs | 4 (16%) | 13 (19%) | >0.99 | |
| Median time to first Episode of ACR/days (IQR) | 56 (41–214) | 31 (30–76) | 0.026 | |
| Number of Patients with Any ISHLT Grade Rejection (%) | 12 (48%) | 36 (54%) | 0.65 | |
| Median cumulative A-grade Rejection Score at 1 year (IQR) | 3 (2–5) | 3 (1–5) | 0.74 | |
| Incomplete Surveillance Bronchoscopy Protocol | 8 (32%) | 28 (42%) | 0.47 | |
| Airway dehiscence within 30 days of Transplant (%) | 1 (4%) | 3 (4%) | >0.99 | |
| Median follow-up/months (IQR) | 22 (18–29) | 30 (19–41) | 0.16 | |
Abbreviations: ILD, interstitial lung disease; LAS, lung allocation score; ECMO, extracorporeal membrane oxygenation; CPB, cardiopulmonary bypass; ACR, acute cellular rejection; CLAD, chronic lung allograft dysfunction
*
At T 0hrs, one patient was ungradable in the AE-ILD group and 3 were ungradable in the stable group. At T 24hrs and 48 hrs, there was one was ungradable patient in each group.