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. 2021 Dec 22;11:756011. doi: 10.3389/fonc.2021.756011

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Copyright © 2021 Liu, Zhao, Huo, Wang, Tigyi, Zhu, Yue and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADSC promote cell growth, migration, and invasion in ovarian cancer cells. (A, B) MTT assay was performed to detect the cell proliferation in OVCAR3 (A) and OVCAR8 (B) cells at different time points, following treatment with ADSC-CM or control medium. (C, D) Cell colony formation assay was performed to determine cell survival in OVCAR3 (C) and OVCAR8 (D) cells treated with ADSC-CM or control medium. (E, F) Cell migration in OVCAR3 (E) and OVCAR8 (F) cells treated with ADSC-CM or control medium performed using Transwell plates. (G, H) Cell invasion in OVCAR3 (G) and OVCAR8 (H) cells treated with ADSC-CM or control medium examined using Matrigel-coated plates. Data represent the mean ± SD of three independent experiments. ^** p < 0.01, ^*** p < 0.001 compared with the control group.