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. 2021 Dec 22;11:756011. doi: 10.3389/fonc.2021.756011

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Copyright © 2021 Liu, Zhao, Huo, Wang, Tigyi, Zhu, Yue and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADSC enhance primary ovarian tumor growth and metastasis in an orthotopic ovarian cancer mouse model. (A) Live animal imaging of primary tumors in ovaries of mice at 4 weeks following intrabursal injection of OVCAR8 cells. Right, the quantitative bioluminescence intensities. (B) H&E staining of primary tumor in ovaries. There are high-grade serous carcinomas involving the ovarian stroma. No normal ovary structure could be seen in the control and ADSC-CM groups. Tumors are indicated by yellow arrows. (C) Primary tumors in ovaries of mice were identified by live animal imaging. (D, E) Tumors in ovaries of mice were dissected, imaged (D), and weighed (E). (F) Western blot analysis of p-SMAD2 and EMT markers in primary ovarian tumors. Right, the quantification analysis of the blots. (G) Metastatic tumors in liver, spleen, kidney, intestine, and stomach of xenografted mice were identified by live animal imaging. (H) H&E staining of metastatic tumors in livers of xenografted mice. Data represent the mean ± SD of three independent experiments. ^** p < 0.01, ^*** p < 0.001 compared with the control group. ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 compared with the corresponding ADSC-CM group.