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. 2021 Jul 21;11(12):3820–3835. doi: 10.1016/j.apsb.2021.07.013

Table 3.

Histological scoring of liver injury.

Group Score indexa
Endothelial cell damage Focal hemorrhage Mixed cellular infiltration Hepatocyte hyperplasia Steatotic hepatocyte
Control Image 1 Image 1 Image 10 Image 1 Image 1
DSS Image 2 Image 1 Image 14 Image 1 Image 1
RTS Image 15 Image 16 Image 17 Image 18 Image 6
RTS + DSS Image 12 Image 4 Image 18 Image 4 Image 5
a

Each score index is presented as histology pies based on individual mouse liver sections. Each pie is divided into slices equal to the number of mice inspected (n = 5 per group) and scored based on the severity of individual liver lesions: normal (white), moderate lesion (yellow), and severe lesion (orange). Detailed scoring method is available in Supporting Information Table S1.