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. 2021 Apr 6;11(12):3889–3907. doi: 10.1016/j.apsb.2021.03.042

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© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Structures of non-cleavable linkers. (A) The structure of MD non-cleavable linker-containing ADCs. Adapted with modification from Ref. 14 © 2016 Nature Publishing Group. (B) The structure of noncleavable ADCs containing an alkyne, a triazole and a piperazine group, respectively. Adapted with modification from Ref. 59 © 2017 American Chemical Society. (C) The structure of noncleavable linker-MMAE-containing ADCs. Adapted with modification from Ref. 60 © 2020 Multidisciplinary Digital Publishing Institute.