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Structures of GSH-cleavable triggers. (A) The structure and release mechanism of an ADC containing a disulfide linker and a disulfide-carbamate linker. Adapted with modification from Ref. 30 © 2017 Royal Society of Chemistry. (B) The structure and release mechanism of an ADC containing a disulfide-carbamate linker with a PBD-dimer. Adapted with modification from Ref. 31 © 2017 American Association for Cancer Research.
