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. 2021 Apr 6;11(12):3889–3907. doi: 10.1016/j.apsb.2021.03.042

Figure 7.

Figure 7

Structures of a pyrophosphate-cleavable trigger and novel leaving group. (A) The structure and release mechanism of Val-Cit-PAB-pyrophosphate linker-containing ADCs. Adapted with modification from Ref. 38 © 2016 American Chemical Society. (B) The structure and release mechanism of pyrophosphate linker-containing ADCs. Adapted with modification from Ref. 39 © 2016 American Chemical Society. (C) The structure and release mechanism of Val-Ala-AHC cleavable linker-containing ADCs. Adapted with modification from Ref. 42 © 2020 Ivyspring International.