Table 3.
All-grade AEs within 4 weeks after first DEB-TACE with frequency ≥10% in either group and corresponding Grades 3 and 4 AEs
| Adverse Event | DEB-TACE+LEN Group (N=50) | DEB-TACE+SOR Group (N=100) | P value | ||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| All grades | Grades 1-2 | Grade 3-4 | All grades | Grades 1-2 | Grades 3-4 | ||
| Abdominal pain | 42 (84) | 32 (64) | 10 (20) | 83 (83) | 68 (68) | 15 (15) | 0.877 |
| Fever | 37 (74) | 30 (60) | 7 (14) | 84 (84) | 72 (72) | 12 (12) | 0.144 |
| Fatigue | 31 (62) | 29 (58) | 2 (4) | 76 (76) | 69 (69) | 7 (7) | 0.074 |
| Nausea and vomiting | 26 (52) | 19 (38) | 7 (14) | 60 (60) | 52 (52) | 8 (8) | 0.350 |
| Decreased appetite | 22 (44) | 18 (36) | 4 (8) | 32 (32) | 28 (28) | 4 (4) | 0.149 |
| Liver dysfunction | 20 (40) | 16 (32) | 4 (8) | 41 (41) | 35 (35) | 6 (6) | 0.906 |
| Hypertension | 19 (38) | 15 (30) | 4 (8) | 30 (30) | 28 (28) | 2 (2) | 0.325 |
| Hand-foot skin reaction | 16 (32) | 11 (22) | 5 (10) | 49 (49) | 36 (36) | 13 (13) | 0.048 |
| Diarrhea | 15 (30) | 12 (24) | 3 (6) | 25 (25) | 20 (20) | 5 (5) | 0.514 |
| Proteinuria | 13 (26) | 9 (18) | 4 (8) | 10 (10) | 7 (7) | 3 (3) | 0.010 |
| Thrombocytopenia | 12 (24) | 8 (16) | 4 (8) | 22 (22) | 15 (15) | 7 (7) | 0.783 |
| Neutropenia | 10 (20) | 7 (14) | 3 (6) | 18 (18) | 14 (14) | 4 (4) | 0.767 |
| Ascites | 8 (16) | 5 (10) | 3 (6) | 14 (14) | 12 (12) | 2 (2) | 0.744 |
| Weight loss | 7 (14) | 7 (14) | 0 | 10 (10) | 9 (9) | 1 (1) | 0.466 |
| Rash | 6 (12) | 5 (10) | 1 (2) | 12 (12) | 8 (8) | 4 (4) | 1.000 |
Note: Data are numbers of events. Data in parentheses are percentages.