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. 2021 Dec 15;11(12):5992–6003.

Figure 6.

Figure 6

Blockade of Jagged/Notch signaling alleviated VTE by downregulating IL-6, TPO and TF expression in a pancreatic cancer mouse model. (A-C) The sera were collected from mice, then the level of IL-6 (A), TPO (B) and TF (C) were determined by ELISA. NC: the mice without any treatment; WT: the mice were implanted with PaTu-8988 cells stably express control shRNA; Jagged1-/- or Jagged2-/-: the mice were implanted with PaTu-8988 which stably express Jagged-1 or Jagged-2 shRNA. (D-F) The sera were collected from mice, then the level of IL-6 (D), TPO (E) and TF (F) were determined by ELISA. NC: the mice without any treatment; WT: the mice were implanted with PaTu-8988 cells; Nirogacestat: the mice were implanted with PaTu-8988 cells and treated with Nirogacestat as described above. (*P<0.05, **P<0.01, ***P<0.001 versus corresponding group).