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A mechanism of hypercoagulability of pancreatic cancer patients which induced by Jagged-Notch/NF-κB/IL-6/JAK-STAT3 feedback loop. Cancer cells induce IL-6 expression in HSF cells by Jagged/Notch/NF-κB axis, then high level of IL-6 promotes Jagged expression through JAK-STAT3 pathway, meanwhile, IL-6 enhances TPO production in liver, followed by TPO enhances hypercoagulable state in the patients.
