Table 3.
Enriched pathways for differentially expressed genes after high glucose treatment
| Term | Count | Gene List | P value | Bonferroni P | Benjamini P |
|---|---|---|---|---|---|
| Genes with increased expression | |||||
| GO:0006270~DNA replication initiation | 4 | MCM10, ORC6, GINS4, CCNE2 | 3.30e-05 | 0.0055 | 0.0055 |
| GO:0006260~DNA replication | 5 | CLSPN, MCM10, ORC6, CDC25A, GINS4 | 2.32e-04 | 0.0380 | 0.0192 |
| Genes with decreased expression | |||||
| hsa04141: Protein processing in endoplasmic reticulum | 7 | SYVN1, HYOU1, DDIT3 (CHOP), CALR, DNAJB11, PDIA4, HSPA5 (BiP) | 1.94e-06 | 6.98e-05 | 6.98e-05 |
| GO:0036498~IRE1-mediated unfolded protein response | 5 | SYVN1, HYOU1, WIPI1, HSPA5 (BiP), DNAJB11 | 3.52e-06 | 0.0014 | 0.0014 |
| GO:0005790~smooth endoplasmic reticulum | 4 | SYVN1, HYOU1, CALR, HSPA5 (BiP) | 1.13e-05 | 0.0010 | 0.0010 |
| GO:0000122~negative regulation of transcription from RNA polymerase II promoter | 9 | PLK3, DDIT3 (CHOP), CALR, JUND, MXD1, FHL1, NR4A2, TRIB3, VEGFA | 2.78e-05 | 0.0108 | 0.0036 |
| GO:0034663~endoplasmic reticulum chaperone complex | 3 | HYOU1, DNAJB11, HSPA5 (BiP) | 1.53e-04 | 0.0141 | 0.0071 |
| short sequence motif: Prevents secretion from ER | 4 | HYOU1, CALR, PDIA4, HSPA5 (BiP) | 1.63e-04 | 0.0207 | 0.0207 |
| GO:0005788~endoplasmic reticulum lumen | 5 | HYOU1, CALR, DNAJB11, PDIA4, HSPA5 (BiP) | 3.01e-04 | 0.0276 | 0.0093 |
| GO:0051087~chaperone binding | 4 | SYVN1, HYOU1, CALR, HSPA5 (BiP) | 4.34e-04 | 0.0487 | 0.0487 |