Table 4.
Summary of the effects of Thapsigargin on HCT116 colorectal cancer cells
| Normal glucose | High glucose | |||
|---|---|---|---|---|
|
|
|
|||
| No thapsigargin | + Thapsigargin | No thapsigargin | + Thapsigargin | |
| Cell growth and proliferation | ||||
| MTT | ↑↑ | ↓↓ | ↑↑↑ | ↓ |
| SRB | ↑↑ | ↓↓ | ↑↑↑ | ↓ |
| Cycline E2 expression | ↑ | ↑ | ↑↑↑ | ↑ |
| Cyclin E2 protein | ↑↑ | ↑ | ↑↑↑ | ↑ |
| ER pathway and genes | ||||
| ATF4 expression | ↑↑ | ↑↑↑↑ | ↑↑ | ↑↑↑ |
| ATF4 protein | ↑ | ↑ | ↑ | ↑↑ |
| BIP expression | ↑↑ | ↑↑ | ↑ | ↑↑↑ |
| BIP protein | ↑↑ | ↑↑↑↑ | ↑ | ↑↑↑ |
| XBP1-v1 mRNA (unspliced) | ↑↑ | ↑↑↑ | ↑ | ↑ |
| XBP1-v2 mRNA (spliced) | ↑ | ↑↑↑ | ↑ | ↑↑↑ |
| XBP-1s (protein) | ↑ | ↑↑ | ↑ | ↑↑↑ |
| Apoptosis genes and response | ||||
| TRIB3 expression | ↑↑ | ↑↑↑↑ | ↑ | ↑↑↑ |
| Cleaved caspase 3 | ↑↑↑ | ↑ | ||
| Annexin V stained cells | ↑↑↑ | ↑↑ | ||