Table 3.
Inhibitors target for p53-MDMX binding
| Inhibitors | Mechanisms of action | References |
|---|---|---|
| Short peptide | ||
| SAH-p53-8 | Binds to p53-binding pocket of MDMX and blocks the p53-MDMX binding | [100] |
| mSF-SAH | Covalently binds to p53-binding pocket of MDMX and blocks the p53-MDMX binding | [101] |
| ATSP-7041 | Binds to MDM2 and MDMX and blocks the p53-MDM2/MDMX bindings | [102] |
| ALRN-6924 | Binds to MDM2 and MDMX and blocks the p53-MDM2/MDMX bindings | [103] |
| Molecular inhibitors | ||
| Compound B1 | Binds to p53-binding pocket of MDMX and blocks the p53-MDMX binding | [104] |
| CTX1 | Binds to MDMX, blocks the p53-MDMX binding, and activates p53 | [105] |
| K-178 | Inhibits the p53-MDMX binding and activates p53 | [106] |
| Protoporphyrin IX | Blocks the p53-MDM2/MDMX bindings and stabilizes p53 and TAp73 | [107] |
| SJ-172550 | Covalently but reversibly binds to p53-binding pocket of MDMX | [108] |
| RO-5963 | dual p53-MDM2 and p53-MDMX inhibitor | [109] |
| Pyrrolopyrimidine 3a | dual p53-MDMX/p53-MDM2 inhibitor | [110] |
| WK298 | Inhibition the binding of p53-MDMX | [111] |