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Seven-step synthesis route of DOTAGA.(SA.FAPi)2 (12): (e) MeCN, K2CO3, 90°C, 48 h, 30%; (f) Pd/C (10%), MeOH, H2, RT, 16 h, 100%; (g) HATU, HOBt, DIPEA, MeCN, RT, 24 h, 43%; (h) DCM/TFA (20:80)%, RT, 48 h; (i) SADE, 0.5 M phosphate buffer pH=7, RT, 48 h; (j) 0.5 M phosphate buffer pH=9, RT, 24 h, 12%.
